Wentzville is primarily served by the Wentzville R-IV School District. The School District is located in Saint Charles County, one of the fastest growing counties in the nation and the fastest growing area in Missouri . The Wentzville School District is geographically located in the western part of the county or 40 miles west of downtown St. Louis.
The District is home to corporate offices and industries such as General Motors (sole producer of GM's full-size van and maker of the Canyon and Colorado pick-up trucks), MasterCard Worldwide, and CenturyLink Telephone Mid-West Operations. The District serves an 89-square mile area including all or part of Dardenne Prairie, Foristell, Lake Saint Louis, O'Fallon and Wentzville.
In the City of Wentzville there are numerous opportunities for higher education. Wentzville is home to Midwest University and Urshan College. Additionally, Lindenwood University and Ranken Technical College host a satellite facility within the city.
In the Wentzville region there are several public and private institutions including the University of Missouri-St Louis, Webster University, St Louis University, Fontbonne University, Washington University, Maryville University, Logan College of Chiropractic, St. Louis Christian College, and the St Louis College of Pharmacy. Within 1 ½ hours of Wentzville is the University of Missouri – Columbia, Stephens College, Columbia College, Westminster College, William Woods College and Hannibal-LaGrange College. The Lewis and Clark Vo-Tech and Pike-Lincoln Technical Center are also in close proximity.